Areas of interest span the basic sciences of chemistry, desiggner and aftinity, through to pharmacology and clinical medicine, in the areas of mycobacterial pathogenesis and TB drug discovery research. Honorary Professor at UCT. His primary research interests are C-type lectin receptors and their role in homeostasis and immunity, with a particular focus on antifungal immunity. His research interests revolve around investigating immune regulation and dysregulation in the context of HIV infection or exposure.

He focuses on Immune ontogeny in HIV exposed infants, placental investigations and pre-term birth, and epithelial immunity in the foreskin. Her Research Unit is involved with clinical research, epidemiology and operational research, and is a treatment site for HIV infected adults and children. Her research interests include HIV vaccine research, microbicide research and other biomedical and behavioural interventions, and she is an investigator in testing two HIV vaccine regimens in late stage clinical development.

He has been an author download canoscan lide 25 driver for windows 10 over manuscripts in the field of infectious посмотреть еще and has an extensive track record in infectious diseases research and practice covering clinical, laboratory and epidemiological aspects.

He is an HIV and TB desiner focused on studying the immune response to these pathogens in affected tissues, and how this relates to what can be observed from the blood. The research goal desogner to improve understanding of the immunopathology of TB and HIV, using this information to aid in developing novel therapeutic approaches and diagnostic biomarkers.

His research has centered on understanding the mechanisms by which the human immune system recognises the Mycobacterium tuberculosis M. His work has affinity designer knife tool free strong affinity designer knife tool free component, asking if both classically and non-classically restricted T cells are associated with infection with M. The affinity designer knife tool free significance of this research is centred on informing the development of novel vaccines and diagnostics for childhood TB.

Her current research focuses on HIV broadly neutralising antibodies and their interplay with the evolving virus. Recent studies published in PloS Pathogens, Nature affinity designer knife tool free Nature Medicine have highlighted the role of viral escape in creating new epitopes and immunotypes, thereby driving the development of neutralisation breadth, with implications for HIV vaccine design. Research interest in tuberculosis and in developing and testing point of care diagnostics suitable for the developing world.

More specifically, the reconstitution of the immune response during antiretroviral treatment, in order to identify correlates of protection including immune mechanisms that lead to reduced susceptibility to TBand pathogenesis such as the Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome, TB-IRIS ; the biosignature of the TB infection spectrum, from latent infection to active disease; preventing TB infection in HIV infected people more effectively; and the pathogenesis of tuberculous meningitis and pericarditis.

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